aeruginosa’s genome, which confer remarkable metabolic flexibility and the ability to adapt to multiple conditions, including the host immune response.
Its pathogenic profile stems from the large and variable arsenal of virulence factors and antibiotic resistance determinants harboured in P. aeruginosa is capable of causing both acute and chronic infections. aeruginosa evolution and its interactions with the host throughout the course of infection.Īs a versatile opportunistic pathogen, P. aeruginosa genome (5 to 7 MB) contributes considerably to its adaptive capacity consequently, genomic studies have provided significant insights into elucidating P. aeruginosa and the adaptations it undergoes to persist in hostile environments such as the CF respiratory tract.
Therefore, this review describes the main virulence factors of P. A deep understanding of these virulence mechanisms is crucial for the design of therapeutic strategies and vaccines against this multi-resistant pathogen. aeruginosa with the facility to tailor its response against the different stressors in the environment. The adaptability and flexibility of the pathogen are afforded by the extensive number of virulence factors it has at its disposal, providing P. Its tremendous ability to adapt greatly facilitates its capacity to cause chronic infections. Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF) contributing to morbidity and mortality.
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